Product ID:L-ASPARAGINASE /ELSPAR/
MSDS Date:08/10/1986
FSC:6505
NIIN:01-153-9650
MSDS Number: BGPFY

MERCK,SHARP & DOHME

WEST POINT, PA 19486
US

Emergency Phone: 215-661-7300

Info Phone: 215-661-5000

Cage: NO055

MERCK-SHARP AND DOHME DIV OF MERCK AND CO INC

WEST POINT, PA 19486 US

Telephone: 215-540-8629

Cage: 06990

L-ASPARAGINASE

CAS: 9015-68-3

RTECS: CI9000000

Fraction By Weight: 6%

MANNITOL

CAS: 69-65-8

RTECS: OP2060000

Fraction By Weight: 94%

Routes of Entry: Inhalation:YES Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:COMPOUND HAS BEEN SHOWN TO CAUSE BIRTH
DEFECTS IN LAB ANIMALS WHEN GIVEN INTRAVENOUSLY AT DOSES IN
THEAPEUTIC RANGE. NOT CONSIDERED A POTENTIAL OCCUPATIONAL HAZARD AS
THE COMPLEX NATURE OF THE COMPOUN D'S STRUCTURE WOULD INHIBIT
ABSORPTION.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:EYES AND SKIN: IRRITATION. INGESTION: NOT
CONSIDERED A POTENTIAL ROUTE OF SYSTEMIC EXPOSURE. INHALATION:
IRRITATION TO UPPER RESPIRATORY TRACT. SOME EXPOSED WORKERS HAVE
EXPERIENCED CHILLS, FEVER, SLI GHT RESPIRATORY DISTRESS AND
DIARRHEA.

First Aid:EYES: FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15
MINUTES. GET MEDICAL ATTENTION. SKIN: WASH IMMEDIATELY WITH SOAP
AND WATER. INHALATION: REMOVE FROM EXPOSURE. GET MEDICAL ATTENTION
IF SYMPTOM S APPEAR. INGESTION: DO NOT INDUCE VOMITING. DILUTE WITH
WATER AND GET MEDICAL ATTENTION.

Flash Point:NONE
Extinguishing Media:WATER SPRAY OR ALL PURPOSE DRY CHEMICAL TO FIGHT
FIRES.
Fire Fighting Procedures:USE SELF-CONTAINED BREATHING APPARATUS AND
PROTECT CLOTHING IF COMPOUND IS RELEASED DURING FIRE OR IS BURNING.
Unusual Fire/Explosion Hazard:NONE

Spill Release Procedures:VACUUM OR SWEEP UP SPILLED MATERIAL. AVOID
CREATION OF AIRBORNE DUST. WEAR SUITABLE PROTECTIVE EQUIPMENT.

Handling and Storage Precautions:MATL IS AN ENZYMATIC PROTEIN. SHOULD
BE STORED BELOW 46F/8C/;UNUSED RECONSTITUTED SOLN SHOULD BE STORED
AT 36-46F/2-8C/ & DISCARDED AFTER 8HRS IF CLOD
Other Precautions:NONE

Respiratory Protection:TOXIC DUST RESPIRATOR OR AIRLINE MASK SHOULD BE
USED IF MATERIAL IS RELEASED TO ATMOSPHERE.
Ventilation:AS NECESSARY TO REMOVE DUST. NOT NECESSARY IF MATERIAL IS
CONTAINED IN VIALS. RECOMMEND USE OF HEPA FILTER.
Protective Gloves:RUBBER OR IMPERVIOUS MATERIAL
Eye Protection:CHEMICAL GOGGLES
Other Protective Equipment:PROTECTIVE OUTER CLOTHING, PREFERRABLY MADE
OF DISPOSABLE MATERIAL, IS RECOMMENDED.
Work Hygienic Practices:MATERIAL SHOULD BE HANDLED IN A LAB HOOD
WHENEVER POSSIBLE. HOOD SHOULD HAVE AN ABSOLUTE FILTER.
Supplemental Safety and Health

HCC:T6
Solubility in Water:COMPLETE
Appearance and Odor:WHITE LYOPHYLLIZED PLUG OR POWDER

Stability Indicator/Materials to Avoid:NO
Stability Condition to Avoid:OPEN CONTAINERS -AT RISK OF BACTERIAL
CONTAMINATION
Hazardous Decomposition Products:NONE

Waste Disposal Methods:IN ACCORDANCE WITH LOCAL, STATE, AND FEDERAL
REGULATIONS. INCINERATION IS THE PREFERRED METHOD.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.